See what’s happening in Small Animal Medicine:
Kindred-Canines In Motion seeks to bring Regenerative Therapies to Service/Assistance Animals
Stem Cell Regenerative Therapy
Soft tissue injuries and osteoarthritis are common conditions in dogs. These injuries are due to the forces placed on the joints and are more common in working dogs because of the repetitive injuries and microtrauma to tendons, ligaments, and articular surfaces. The degenerative arthritic changes progress throughout a dog’s life.
Most therapies treat symptoms or may slow the progression of osteoarthritis. Stem cell therapy treats symptoms, slows the disease, decreases pain and consumption of pain medications, and repairs some or most of the damaged tissue. It will improve a Service/Assistance Dog’s quality of life.
What are stem cells?
A stem cell is characterized by its ability to divide and create another cell like itself and by its potential to become many different types of cells. There are two broad types of stem cells:
Embryonic stem cells – Found in a developing embryo, embryonic stem cells are intended to form a whole animal or organ and have unlimited potential of development into any type of tissue. In human medicine, ethical and legal debates surround the use of embryonic stem cells for research and therapy; such controversy does not exist with the use of adult stem cells.
Adult stem cells – Found in most adult tissues, adult stem cells act as a repair system for the body, replenishing specialized cells and maintaining the normal turnover of regenerative organs, such blood, skin, or cartilage. Adult stem cells are also multi-potent, meaning the cells have the potential to differentiate themselves to become various types of cells
How are canine stem cells obtained?
In dogs, stem cells and other regenerative cells are obtained from short surgical procedure to collect the subcutaneous or abdominal adipose tissue (fat). Adipose tissue is a preferred source in dogs over bone marrow for several reasons, including ease of access, high-yielding stem cell count as compared to bone marrow, and the fact that fat is a renewable source. The stem cells, along with a mix of other regenerative cells within the adipose tissue, are isolated and then injected directly into the injured tissue or joint and/or injected intravenously. These cells are always obtained from the intended recipient (autograft), eliminating the risk of rejection and disease transmission.
The mechanisms by which these regenerative and stem cells initiate change within the body is complex. When an injury occurs, chemical signals and pathways are created that lead stem cells to the area of trauma. The stem cells then release growth factors and other chemicals that provide local healing, reduce inflammation and promote damaged tissue regeneration.
Which dogs are good candidates?
- Dogs that have not responded to non-steroidal anti-inflammatory drugs
- Dogs that cannot tolerate non-steroidal anti-inflammatory drugs
- Dogs that are not good candidates for orthopedic surgery
- Dogs that have early arthritis
- Dogs that have multiple joints affected by arthritis
Please contact us to schedule an evaluation by calling Dr. Gerardi and her staff at (919) 618-0809.
“Dugan” A Service Dog With Severe Degenerative Arthritis
“Dually”, A 4 Year Old Mastiff With An Acute Injury
“Dr. Gerardi …… Sunny has come up the stairs now 3 times! Sunny has NEVER come up the stairs in the past 6 years since we have had him. We were very impressed! Sunny has made it up and down the stairs now with confidence. Thank you so much for blessing us with the gift of Stem Cell Therapy.” – Mrs. Anitra Ruth and Sunny